Anti-STAT4 Antibody Picoband®

SKU: PA1692

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Gene Name: STAT4

Specificity: No cross reactivity with other proteins.

Background: STAT4 is a human gene. The protein encoded by this gene is a member of the STAT protein family of transcription factors. STAT4 is mapped to chromosome 2q32.2-q32.3 by fluorescence in situ hybridization. STAT4 is phosphorylated in response to interleukin-12 and is essential for IL12 signal transduction. Transactivation, electrophoretic mobility shift, and RNA interference analyses showed that Ikaros bound to the STAT4 promoter and was involved in regulation of STAT4 in human T cells.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human STAT4, identical to the related rat and mouse sequences.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Frucht, D. M., Aringer, M., Galon, J., Danning, C., Brown, M., Fan, S., Centola, M., Wu, C.-Y., Yamada, N., Gabalaway, H. E., O'Shea, J. J.Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.J. Immun. 164: 4659-4664, 2000. 2. Pang, Y. H., Zheng, C. Q., Yang, X. Z., Zhang, W. J.Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.Cell. Immunol. 248: 115-120, 2007. 3. Yap, W.-H., Yeoh, E., Tay, A., Brenner, S., Venkatesh, B.STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.FEBS Lett. 579: 4470-4478, 2005.

Uniprot ID: Q14765

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 86 kDa

Calculated Molecular Weight: 86 kDa

Gene ID: 6775

Protein Name: Signal transducer and activator of transcription 4

Gene Full Name: signal transducer and activator of transcription 4

Synonyms: SLEB11; STAT4