Anti-ST8SIA2 Antibody Picoband®

SKU: A05894-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: ST8SIA2

Specificity:

Background: Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene. The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.

Immunogen: E.coli-derived human ST8SIA2 recombinant protein (Position: D69-R267).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Angata, K., Long, J. M., Bukalo, O., Lee, W., Dityatev, A., Wynshaw-Boris, A., Schachner, M., Fukuda, M., Marth, J. D. Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that s hippocampal axonal targeting and promotes fear behavior. J. Biol. Chem. 279: 32603-32613, 2004. 2. Angata, K., Nakayama, J., Fredette, B., Chong, K., Ranscht, B., Fukuda, M. Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule: tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. J. Biol. Chem. 272: 7182-7190, 1997. 3. Angata, K., Suzuki, M., McAuliffe, J., Ding, Y., Hindsgaul, O., Fukuda, M. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha-2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. J. Biol. Chem. 275: 18594-18601, 2000.

Uniprot ID: Q92186

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 39 kDa

Calculated Molecular Weight:

Gene ID: 8128

Protein Name: Alpha-2,8-sialyltransferase 8B

Gene Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Synonyms: Alpha 2; 8 sialyltransferase 8B; HsT19690; Sialyltransferase 8B; Sialyltransferase X; Sialytransferase St8Sia II; SIAT8 B; SIAT8B; ST8SIA II; ST8SIA2; ST8SiaII; STX