Anti-RAB23 Antibody Picoband®

SKU: A04593-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: RAB23

Specificity:

Background: Ras-related protein Rab-23 is a protein that in humans is encoded by the RAB23 gene. This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human RAB23 recombinant protein (Position: K22-K168).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Alessandri, J.-L., Dagoneau, N., Laville, J.-M., Baruteau, J., Hebert, J.-C., Cormier-Daire, V. RAB23 mutation in a large family from Comoros Islands with Carpenter syndrome. Am. J. Med. Genet. 152A: 982-986, 2010. 2. Eggenschwiler, J. T., Espinoza, E., Anderson, K. V. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412: 194-198, 2001. 3. Gunther, T., Struwe, M., Aguzzi, A., Schughart, K. open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development 120: 3119-3130, 1994.

Uniprot ID: Q9ULC3

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 27 kDa

Calculated Molecular Weight:

Gene ID: 51715

Protein Name: Ras-related protein Rab-23

Gene Full Name: RAB23, member RAS oncogene family

Synonyms: HSPC137; RAB23; Ras related protein Rab 23