Anti-PRODH Antibody Picoband®

SKU: A03231-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: PRODH

Specificity:

Background: Proline dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the PRODH gene. This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen: E.coli-derived human PRODH recombinant protein (Position: H116-E433).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Afenjar, A., Moutard, M.-L., Doummar, D., Guet, A., Rabier, D., Vermersch, A.-I., Mignot, C., Burglen, L., Heron, D., Thioulouse, E., de Villemeur, T. B., Campion, D., Rodriguez, D. Early neurological phenotype in 4 children with biallelic PRODH mutations. Brain Dev. 29: 547-552, 2007. 2. Baron, M. Genetics of schizophrenia and the new millennium: progress and pitfalls. Am. J. Hum. Genet. 68: 299-312, 2001. 3. Bender, H.-U., Almashanu, S., Steel, G., Hu, C.-A., Lin, W.-W., Willis, A., Pulver, A., Valle, D. Functional consequences of PRODH missense mutations. Am. J. Hum. Genet. 76: 409-420, 2005.

Uniprot ID: O43272

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 69 kDa

Calculated Molecular Weight: 37836 MW

Gene ID: 5625

Protein Name: Proline dehydrogenase 1, mitochondrial

Gene Full Name: proline dehydrogenase 1

Synonyms: HSPOX2; p53 induced gene 6 protein; PIG6; POX; POX2; PRODH; PRODH1; Proline oxidase; Proline oxidase 2; SCZD4; TP53I6