Anti-PHYHIPL Antibody Picoband®

SKU: A14122-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: PHYHIPL

Specificity:

Background: Phytanoyl-CoA hydroxylase-interacting protein-like is an enzyme that in humans is encoded by the PHYHIPL gene. PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein-like), also known as phytanoyl-CoA hydroxylase-interacting protein-like, is a 376 amino acid protein that contains one fibronectin type-III domain and belongs to the PHYHIP family. Conserved in chimpanzee, canine, mouse, rat, chicken, zebrafish and Caenorhabditis elegans, PHYHIPL exists as three alternatively spliced isoforms. PHYHIPL is a down-regulated target of IRX1, a homeobox tumor suppressor gene linked to gastric carcinoma. PHYHIPL may also play a role in the development of the central system. The gene that encodes PHYHIPL maps to human chromosome 10q21.1.

Immunogen: E.coli-derived human PHYHIPL recombinant protein (Position: M1-D336). Human PHYHIPL shares 97.3% and 96.7% amino acid (aa) sequence identity with mouse and rat PHYHIPL, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Fu, H., Ge, B., Chen, D., Wu, Y., Luo, Q., Li, X., ... & Tang, Q. (2019). Phytanoyl-CoA 2-hydroxylase-interacting protein-like gene is a therapeutic target gene for glioblastoma multiforme. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 25, 2583. 2. Sugimoto, H., Horii, T., Hirota, J. N., Sano, Y., Shinoda, Y., Konno, A., ... & Sadakata, T. (2021). The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Molecular Brain, 14, 1-9. 3. Ying, H., Zheng, H., Scott, K., Wiedemeyer, R., Yan, H., Lim, C., ... & DePinho, R. A. (2010). Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences, 107(15), 6912-6917.

Uniprot ID: Q96FC7

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 40 kDa

Calculated Molecular Weight: 42,40,6 kDa

Gene ID: 84457

Protein Name: Phytanoyl-CoA hydroxylase-interacting protein-like

Gene Full Name: phytanoyl-CoA 2-hydroxylase interacting protein like

Synonyms: PHYHIPL; KIAA1796; UNQ6309/PRO20934; Phytanoyl-CoA hydroxylase-interacting protein-like