Anti-PGC1 beta/PPARGC1B Picoband® Antibody

SKU: A02933-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.1-0.25μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human, Mouse
ELISA, 0.1-0.5μg/ml, -

Gene Name: PPARGC1B

Specificity: No cross reactivity with other proteins.

Background: Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. It is mapped to 5q32. The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.

Immunogen: E.coli-derived human PGC1 beta/PPARGC1B recombinant protein (Position: A8-P375).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Andersen, G., Wegner, L., Yanagisawa, K., Rose, C. S., Glumer, C., Drivsholm, T., Borch-Johnsen, K., Jorgensen, T., Hansen, T., Spiegelman, B. M., Pedersen, O. Evidence of an association between genetic variation of the coactivator PGC-1-beta and obesity. J. Med. Genet. 42: 402-407, 2005. 2. Hentschke, M., Susens, U., Borgmeyer, U. PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. Biochem. Biophys. Res. Commun. 299: 872-879, 2002. 3. Ishii, K., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., Ikeda, K. Coordination of PGC-1-beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nature Med. 15: 259-266, 2009.

Uniprot ID: Q86YN6

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 113 kDa

Calculated Molecular Weight: 79686 MW

Gene ID: 133522

Protein Name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Gene Full Name: PPARG coactivator 1 beta

Synonyms: ERRL1; PERC; PGC 1 beta; PGC 1(beta); PGC1; PGC1B; PPAR gamma coactivator 1 beta; PPARGC 1 beta; PPARGC1; PPARGC1B