Anti-PDE10A Antibody Picoband®

SKU: A02605-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Mouse
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: PDE10A

Specificity:

Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.

Immunogen: E.coli-derived human PDE10A recombinant protein (Position: H515-D779).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Diggle, C. P., Sukoff Rizzo, S. J., Popiolek, M., Hinttala, R., Schulke J.-P., Kurian, M. A., Carr, I. M., Markham, A. F., Bonthron, D. T., Watson, C., Sharif, S. M., Reinhart, V., and 30 others. Biallelic mutations in PDE10A lead to loss of striatal PDE10A and a hyperkinetic movement disorder with onset in infancy. Am. J. Hum. Genet. 98: 735-743, 2016. 2. Fujishige, K., Kotera, J., Michibata, H., Yuasa, K., Takebayashi, S., Okumura, K., Omori, K. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J. Biol. Chem. 274: 18438-18445, 1999. 3. Fujishige, K., Kotera, J., Yuasa, K., Omori, K. The human phosphodiesterase PDE10A gene: genomic organization and evolutionarily relatedness with other PDEs containing GAF domains. Europ. J. Biochem. 267: 5943-5951, 2000.

Uniprot ID: Q9Y233

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 100 kDa

Calculated Molecular Weight: 35487 MW

Gene ID: 10846

Protein Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Gene Full Name: phosphodiesterase 10A

Synonyms: HSPDE10A; PDE10A; phosphodiesterase 10A