Anti-NR1D2 Antibody Picoband®

SKU: A04958-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: NR1D2

Specificity:

Background: This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.

Immunogen: E.coli-derived human NR1D2 recombinant protein (Position: K56-E501). Human NR1D2 shares 88.8% and 87.2% amino acid (aa) sequence identity with mouse and rat NR1D2, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., Liddle, C., Auwerx, J., Downes, M., Panda, S., Evans, R. M. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485: 123-127, 2012. 2. Ding, G., Li, X., Hou, X., Zhou, W., Gong, Y., Liu, F., He, Y., Song, J., Wang, J., Basil, P., Li, W., Qian, S., and 10 others. REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. Nature 592: 763-767, 2021. Note: Erratum: Nature 595: E2, 2021. 3. Dumas, B., Harding, H. P., Choi, H.-S., Lehmann, K. A., Chung, M., Lazar, M. A., Moore, D. D. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. Molec. Endocr. 8: 996-1005, 1994.

Uniprot ID: Q14995

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 68 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 9975

Protein Name: Nuclear receptor subfamily 1 group D member 2

Gene Full Name: nuclear receptor subfamily 1 group D member 2

Synonyms: NR1D2; Nuclear receptor subfamily 1 group D member 2; Orphan nuclear hormone receptor BD73; Rev-erb alpha-related receptor; RVR; Rev-erb-beta; V-erbA-related protein 1-related; EAR-1R