Anti-L17A Receptor/IL17RA Antibody Picoband®

SKU: A01311-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: ELISA, 0.1-0.5μg/ml, -, Western blot, 0.1-0.5μg/ml, Human,

Gene Name: IL17RA

Specificity: No cross reactivity with other proteins.

Background: Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. The IL17R gene is mapped to 22q11.22-q11.23 by radiation hybrid analysis. Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.

Immunogen: E. coli-derived human IL17RA recombinant protein (Position: K53-Q284). Human IL17RA shares 74.1% amino acid (aa) sequence identity with mouse IL17RA.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: IL17RA interleukin 17 receptor A. 2. Yao, Z., Spriggs, M. K., Derry, J. M. J., Strockbine, L., Park, L. S., VandenBos, T., Zappone, J., Painter, S. L., Armitage, R. J. Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9: 794-800, 1997. 3. Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., Spriggs, M. K. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3: 811-821, 1995.

Uniprot ID: Q96F46

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 120-150 kDa

Calculated Molecular Weight: 96122 MW

Gene ID: 23765

Protein Name: Interleukin-17 receptor A

Gene Full Name: interleukin 17 receptor A

Synonyms: interleukin 17 receptor A; CANDF5; CD217; CDw217; IL-17RA; IL17R; IMD51; hIL-17R; IL17RA; IL 17RA