Anti-Involucrin Ivl Antibody (Monoclonal, SY5)

SKU: MA1053

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Pig

Applications: IHC,ICC,WB

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.4-1μg/ml, Human, pig
Immunocytochemistry , 1μg/ml, Human, pig, -
Immunohistochemistry (Frozen Section), 0.4-1μg/ml, Human, pig, -
Western blot, 1μg/ml, Human, pig

Gene Name: IVL

Specificity: No cross reactivity with other proteins.

Background: Involucrin is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. The gene consists of 585 amino acids, 390 of which form a central decapeptide repeat, rich in glutamine and glutamic acid. The involucrin gene, encoding a protein of the terminally differentiated keratinocyte, is polymorphic in the human. Involucrin has previously been mapped to chromosome 1q21. The epidermal protein involucrin has been remodeled in the higher primates. And the existence of two populations of East Asian involucrin alleles gives support for the existence of a Eurasian stem lineage from which Caucasians and a part of the Asian population originated.

Immunogen: Human involucrin.

Clonality: Monoclonal

Contents: Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3. *This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Ascites

Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Reference: 1. Eckert, R. L.; Green, H. : Structure and evolution of the human involucrin gene. Cell 46: 583-589, 1986. 2. Djian, P.; Delhomme, B.; Green, H. : Origin of the polymorphism of the involucrin gene in Asians. Am. J. Hum. Genet. 56: 1367-1372, 1995.

Uniprot ID: P48998

Host: Mouse

Concentration: Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Mouse IgG1

Phospho_site:

Clone Number: Clone: SY5

Observed Molecular Weight: 68 kDa

Calculated Molecular Weight: 67021 MW

Gene ID: Human(3713), Mouse(16447), Rat(60583)

Protein Name: Involucrin

Gene Full Name: involucrin

Synonyms: Involucrin;Ivl