Anti-IMPDH2 Antibody Picoband®

SKU: A03021-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: Flow Cytometry,IF,IHC,ICC,WB

Application Details: Western blot, 0.25-0.5 μg/ml/ml, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/ml/1x10^6 cells, Human

Gene Name: IMPDH2

Specificity:

Background: Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IMPDH2, identical to the related mouse and rat sequences.s

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Glesne, D. A., Huberman, E. Cloning and sequencing of the human type II IMP dehydrogenase gene. Biochem. Biophys. Res. Commun. 205: 537-544, 1994. 2. Glesne, D., Collart, F., Varkony, T., Drabkin, H., Huberman, E. Chromosomal localization and structure of the human type II IMP dehydrogenase gene (IMPDH2). Genomics 16: 274-277, 1993. 3. Kost-Alimova, M. V., Glesne, D. A., Huberman, E., Zelenin, A. V. Assignment of inosine 5-prime-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. Cytogenet. Cell Genet. 82: 145-146, 1998.

Uniprot ID: P12268

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 56 kDa

Calculated Molecular Weight:

Gene ID: 3615

Protein Name: Inosine-5'-monophosphate dehydrogenase 2

Gene Full Name: inosine monophosphate dehydrogenase 2

Synonyms: IMP dehydrogenase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH2