Anti-Glycodelin/PAEP Antibody Picoband®

SKU: A06051-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: Western blot, 0.1-0.25 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: PAEP

Specificity:

Background: Glycodelin (GD) also known as human placental protein-14 (PP-14) progestogen-associated endometrial protein (PAEP) or pregnancy-associated endometrial alpha-2 globulin is a glycoprotein that inhibits cell immune function and plays an essential role in the pregnancy process. In humans is encoded by the PAEP gene. This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human Glycodelin/PAEP recombinant protein (Position: M19-F180).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bell, K., Hopper, K. E., McKenzie, H. A., Murphy, W. H., Shaw, D. C. A comparison of bovine alpha-lactalbumin A and B of Droughtmaster. Biochim. Biophys. Acta 214: 437-444, 1970. 2. Bell, K., McKenzie, H. A., Murphy, W. H., Shaw, D. C. Beta-lactoglobulin (Droughtmaster): a unique protein variant. Biochim. Biophys. Acta 214: 427-436, 1970. 3. Chan, P., Simon-Chazottes, D., Mattei, M. G., Guenet, J. L., Salier, J. P. Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24P3, and progestagen-associated endometrial protein map to HSA9 and MMU2. Genomics 23: 145-150, 1994.

Uniprot ID: P09466

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 24 kDa

Calculated Molecular Weight: 80420 MW

Gene ID: 5047

Protein Name: Glycodelin

Gene Full Name: progestagen associated endometrial protein

Synonyms: GD; GdA; GdF; GdS; Glycodelin; PAEG; PAEP; PEG; PEP; Placental protein 14; PP14