Anti-GHRHR Antibody Picoband®

SKU: A04230-2

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml

Gene Name: GHRHR

Specificity:

Background: This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.

Immunogen: E.coli-derived human GHRHR recombinant protein (Position: H23-K407). Human GHRHR shares 84.8% and 85.6% amino acid (aa) sequence identity with mouse and rat GHRHR, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Aguiar-Oliveira, M. H., Gill, M. S., de A. Barretto, E. S., Alcantara, M. R. S., Miraki-Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A., Salvatori, R., Levine, M. A., Shalet, S. M., Camacho-Hubner, C., Clayton, P. E. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J. Clin. Endocr. Metab. 84: 4118-4126, 1999. 2. DeAlmeida, V. I., Mayo, K. E. Identification and binding domains of the growth hormone-releasing hormone receptor by analysis of mutant and chimeric receptor proteins. Molec. Endocr. 12: 750-765, 1998. 3. Gaylinn, B. D., Harrison, J. K., Zysk, J. R., Lyons, C. E., Lynch, K. R., Thorner, M. O. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Molec. Endocr. 7: 77-84, 1993.

Uniprot ID: Q02643

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 47 kDa

Calculated Molecular Weight: 47 kDa

Gene ID: 2692

Protein Name: Growth hormone-releasing hormone receptor

Gene Full Name: growth hormone releasing hormone receptor

Synonyms: GHRFR; GHRH receptor; GHRHR; GHRHRpsv; GRF receptor; GRFR