Anti-Galactosidase alpha/Gla Antibody Picoband®

SKU: A01135-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB,IHC

Application Details: Western blot, 0.25-0.5μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human

Gene Name: GLA

Specificity:

Background: Alpha-galactosidase is a glycoside hydrolase enzyme that encoded by the GLA gene. This gene is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Galactosidase alpha/Gla.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: GLA galactosidase, alpha. 2. Calhoun DH, Bishop DF, Bernstein HS, Quinn M, Hantzopoulos P, Desnick RJ (1985). Fabry disease: isolation of a cDNA clone encoding human alpha-galactosidase A. Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7364–8. 3. Keating GM (October 2012). Agalsidase alfa: a review of its use in the management of Fabry disease. BioDrugs. 26 (5): 335–54.

Uniprot ID: P06280

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 49 kDa

Calculated Molecular Weight: 47643 MW

Gene ID: 2717

Protein Name: Alpha-galactosidase A

Gene Full Name: galactosidase alpha

Synonyms: Alpha galactosidase A; galactosidase; alpha