Anti-FOXN1 Antibody Picoband®

SKU: A03369-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: Flow Cytometry,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human

Gene Name: FOXN1

Specificity:

Background: The FOXN1 gene encodes a transcription factor that regulates the development of epithelial cells in the thymus and skin. FOXN1 is expressed in thymic epithelial cell precursors which interact with T-cell progenitors for T-cell development in the thymus, and thus plays an essential role in thymic development beginning in the embryo. FOXN1 is also expressed in keratinocytes, hair follicles, epithelial cells in the nail matrix bed, and cells of the choroid plexus.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human FOXN1, which shares 85.7% amino acid (aa) sequence identity with mouse FOXN1.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Adriani, M., Martinez-Mir, A., Fusco, F., Busiello, R., Frank, J., Telese, S., Matrecano, E., Ursini, M. V., Christiano, A. M., Pignata, C. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. Ann. Hum. Genet. 68: 265-268, 2004. 2. Amorosi, S., D'Armiento, M., Calcagno, G., Russo, I., Adriani, M., Christiano, A. M., Weiner, L., Brissette, J. L., Pignata, C. FOXN1 homozygous mutation associated with anencephaly and severe neural tube defect in human athymic Nude/SCID fetus. Clin. Genet. 73: 380-384, 2008. 3. Auricchio, L., Adriani, M., Frank, J., Busiello, R., Christiano, A., Pignata, C. Nail dystrophy associated with a heterozygous mutation of the nude/SCID human FOXN1 (WHN) gene. Arch. Derm. 141: 647-648, 2005.

Uniprot ID: O15353

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 69 kDa

Calculated Molecular Weight:

Gene ID: 8456

Protein Name: Forkhead box protein N1

Gene Full Name: forkhead box N1

Synonyms: FKHL20; forkhead box N1; Forkhead box protein N1; FOXN1; RONU; WHN