Anti-epithelial Sodium Channel alpha/SCNN1A Antibody Picoband®

SKU: A01413-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SCNN1A

Specificity:

Background: The SCNN1A gene encodes the alpha subunit of the epithelial sodium channel (ENaC), a constitutively active channel that allows the flow of sodium ions from the lumen into epithelial cells across the apical cell membrane. The ENaC channel, which is regulated by the renin-angiotensin-aldosterone system, has a central role in the regulation of extracellular fluid volume and blood pressure. The other subunits are encoded by the beta (SCNN1B), gamma (SCNN1G), and delta (SCNN1D) genes. This SCNN1A gene is mapped to 12p13.31. Mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.

Immunogen: E.coli-derived human epithelial Sodium Channel alpha/SCNN1A recombinant protein (Position: E8-Q628).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Hanukoglu, I., Hanukoglu, A. Epithelial sodium channel (ENaC) family: phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene 579: 95-132, 2016. 2. Iwai, N., Baba, S., Mannami, T., Ogihara, T., Ogata, J. Association of a sodium channel alpha subunit promoter variant with blood pressure. J. Am. Soc. Nephrol. 13: 80-85, 2002.

Uniprot ID: P37088

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 70 kDa

Calculated Molecular Weight:

Gene ID: 6337

Protein Name: Epithelial sodium channel subunit alpha

Gene Full Name: sodium channel epithelial 1 subunit alpha

Synonyms: Alpha ENaC; Alpha NaCH; ENaCa; ENaCalpha; FLJ21883; SCNEA; SCNN1; SCNN1A