Anti-Cytochrome p450 2C19/CYP2C19 Antibody Picoband® (monoclonal, 5G4)

SKU: M02102-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC

Application Details: Western blot, 0.1-0.5μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human

Gene Name: CYP2C19

Specificity:

Background: Cytochrome P450 2C19 (abbreviatedCYP2C19) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Cytochrome p450 2C19/CYP2C19.

Clonality: Monoclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19. 2. Fleming I (October 2014). The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease. Pharmacological Reviews. 66 (4): 1106–40.

Uniprot ID: P33261

Host: Mouse

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Mouse IgG2b

Phospho_site:

Clone Number: Clone: 5G4

Observed Molecular Weight: 55 kDa

Calculated Molecular Weight:

Gene ID: 1557

Protein Name: Cytochrome P450 2C19

Gene Full Name: cytochrome P450 family 2 subfamily C member 19

Synonyms: (R) limonene 6 monooxygenase; (S) limonene 6 monooxygenase; (S) limonene 7 monooxygenase; CPCJ; CYP2C; CYP2C19; CYPIIC17; CYPIIC19; Cytochrome P450 11A; Cytochrome P450 254C; Cytochrome P450 2C19; Mephenytoin 4 hydroxylase; P450C2C; P450IIC19