ALKBH8 Polyclonal Antibody

SKU: E-AB-52350

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:ALKBH8

Target Synonym:4930562C03Rik;8030431D03Rik;9430088N01Rik;ABH8;alkB alkylation repair homolog 8 (E. coli);alkB alkylation repair homolog 8;AlkB homologue 8;ALKB8;ALKBH8;Alkylated DNA repair protein alkB homolog 8;FLJ38204;MGC10235;OTTHUMP00000211286;OTTHUMP00000211287;Probable alpha-ketoglutarate-dependent dioxygenase ABH8;RGD1304687;S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8;tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8

Research Areas:Cancer;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q96BT7

Accession:

Background:ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.

Concentration:0.6 mg/mL

Immunogen:Full length fusion protein

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000;IHC 1:25-1:100

Calculated MW:75 kDa

ObservedMW:Refer to figures