AIFM1 Polyclonal Antibody

SKU: E-AB-70181

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:AIFM1

Target Synonym:AIFM1;AIFM1;Apoptosis inducing factor 1;mitochondrial;Apoptosis inducing factor;Apoptosis inducing factor;mitochondrion associated;1;Apoptosis-inducing factor 1;CMTX4;COWCK;COXPD6;Harlequin;Hq;mAIF;MGC111425;MGC5706;mitochondrial;Neuropathy;axonal motor-sensory;with deafness and mental retardation;neuropathy;axonal;motor-sensory with deafness and mental retardation (Cowchock syndrome);PDCD 8;PDCD8;Programmed cell death 8 (apoptosis inducing factor);Programmed cell death 8;Programmed cell death 8 isoform 1;Programmed cell death 8 isoform 2;Programmed cell death 8 isoform 3;Programmed cell death protein 8;Programmed cell death protein 8 mitochondrial;Programmed cell death protein 8 mitochondrial precursor;Programmed cell death protein 8 mitochondrial precursor;Striatal apoptosis inducing factor

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O95831,Q9Z0X1,Q9JM53

Accession:

Background:This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Concentration:0.98 mg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to Mouse AIF

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:300-1:1000

Calculated MW:

ObservedMW: