AIF Monoclonal Antibody

SKU: BT-MCA2541

Size:100μL

Background:This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10

Research_area:Others

Target_protein:AIF

applications:WB, IHC, ICC, FCM

Reactivity:Human, Mouse, Monkey, Rat

Clonality:Monoclonal

Clone ID:4E7

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:AIF

Immunogen:Purified recombinant fragment of human AIF expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):67kDa

UniProt accession:O95831

Synonyms:AIFM1, AIF, PDCD8, COXPD6, MGC111425

GeneID:9131