ADO Antibody - Cat. #: CSB-PA934409

SKU: CSB-PA934409

Size :50ul

Clone Number:

Aliases:2 aminoethanethiol dioxygenase antibody; 2-aminoethanethiol dioxygenase antibody; ADO 2 aminoethanethiol (cysteamine) dioxygenase antibody; ADO antibody; AEDO_HUMAN antibody; C10orf22 antibody; Chromosome 10 open reasing frame 22 antibody; cysteamine (2-aminoethanethiol) dioxygenase (ADO) antibody; Cysteamine dioxygenase antibody; DKFZp564C046 antibody; FLJ14547 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96SZ5

Immunogen:Synthetic peptide of Human ADO

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:10000, WB:1:1000-1:5000, IHC:1:25-1:100

Background:Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ADO

Research Areas:Metabolism;Signal transduction