Abl1(Phospho Tyr204) Polyclonal Antibody

SKU: BT-AP05950

Size:100μL

Background:This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes| including cell division| adhesion| differentiation| and response to stress. The activity of the protein is negatively regulated by its SH3 domain| whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants| which contain alternative first exons that are spliced to the remaining common exons.

Research_area:Cancer; Epigenetics and nuclear signaling; Signal transduction

Target_protein:ABL1

applications:WB, IHC-p, IF, ELISA

Reactivity:Human, Mouse, Rat, Monkey

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Tyrosine-protein kinase ABL1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):122873

UniProt accession:Human: P00519; Mouse: P00520

Synonyms:Tyrosine-protein kinase ABL1; ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150

GeneID:Human: 25; Mouse: 11350