ABL1 Monoclonal Antibody

SKU: BT-MCA2718

Size:100μL

Background:ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Research_area:Signal Transduction, Cancer

Target_protein:ABL1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:7B11D6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ABL1

Immunogen:Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P00519

Synonyms:ABL, JTK7, p150, c-ABL, v-abl

GeneID:25