Size :50ug
Clone Number:
Aliases:A2m antibody; A2MG_HUMAN antibody; Alpha 2 M antibody; Alpha 2M antibody; Alpha-2-M antibody; Alpha-2-macroglobulin antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody; CPAMD5 antibody; DKFZp779B086 antibody; FWP007 antibody; S863 7 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P01023
Immunogen:Recombinant Human Alpha-2-macroglobulin protein (1216-1467AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Is able to inhibit all four classes of proteinases by a unique \'trapping\' mechanism. This protein has a peptide stretch, called the \'bait region\' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:HRP
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:A2M
Research Areas:Cardiovascular; Cell biology