MMP12 antibody , Cat. # FNab05234

SKU: FNab05234

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).

Immunogen:matrix metallopeptidase 12(macrophage elastase)

Synonyms:HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12

Observed MW:54 kDa, 45 kDa

Uniprot ID:P39900

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC, IF

Recommended dilution:WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Gene ID:4321

Research Area:Cardiovascular, Metabolism