LRP6 Antibody - Cat. #: CSB-PA013102ESR2HU

SKU: CSB-PA013102ESR2HU

Size :50ul

Clone Number:

Aliases:ADCAD2 antibody; C030016K15Rik antibody; Cd antibody; FLJ90062 antibody; FLJ90421 antibody; LDL receptor related protein 6 antibody; Low density lipoprotein receptor related protein 6 antibody; Low-density lipoprotein receptor-related protein 6 antibody; LRP-6 antibody; LRP6 antibody; LRP6_HUMAN antibody; OTTHUMP00000238979 antibody; OTTHUMP00000238980 antibody; OTTHUMP00000238982 antibody; STHAG7 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75581

Immunogen:Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LRP6

Research Areas:Signal transduction; Stem cells