See Below for Detailed Description
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Updated Date: Stock Protein updated on 20170405
Research areas: Signal Transduction
Target / Protein: NPPB
Biologically active: Not Tested
Expression system: E.coli
Species of origin: Homo sapiens (Human)
Delivery time: 3-7 business days
Uniprot ID: P16860
AA Sequence: DLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESP
Tag info: N-terminal GST-tagged
Expression Region: 37-71aa
Protein length: Partial
MW: 31 kDa
Alternative Name(s): Gamma-brain natriuretic peptide
Relevance: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Reference: "Human and canine gene homologs of porcine brain natriuretic peptide." Seilhamer J.J., Arfsten A., Miller J.A., Lundquist P., Scarborough R.M., Lewicki J.A., Porter J.G. Biochem. Biophys. Res. Commun. 165:650-658(1989)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.