ZFP36L2 Antibody - Cat. #: CSB-PA026450LA01HU

SKU: CSB-PA026450LA01HU

Size :50ug

Clone Number:

Aliases:BRF2 antibody; Butyrate response factor 2 antibody; C3H1 type-like 2 antibody; EGF response factor 2 antibody; EGF-response factor 2 antibody; ERF 2 antibody; ERF-2 antibody; ERF2 antibody; Protein TIS11D antibody; RNF162C antibody; TIS11D antibody; TISD_HUMAN antibody; ZFP36 like 2 antibody; ZFP36 ring finger protein like 2 antibody; ZFP36-like 2 antibody; Zfp36l2 antibody; Zinc finger protein 36 antibody; Zinc finger protein 36, C3H type like 1 antibody; zinc finger protein 36, C3H type like 2 antibody; Zinc finger protein 36, C3H1 type like 2 antibody; Zinc finger protein, C3H type, 36 like 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P47974

Immunogen:Recombinant Human mRNA decay activator protein ZFP36L2 protein (219-321AA)

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3\\\'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3\\\'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ZFP36L2

Research Areas:Epigenetics and Nuclear Signaling; Cell biology