ZAP70 Monoclonal Antibody

SKU: BT-MCA2633

Size:100μL

Background:ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Research_area:Immunology

Target_protein:ZAP70

applications:WB, IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:3D2A4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ZAP70

Immunogen:Purified recombinant fragment of human ZAP70 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):70kDa

UniProt accession:P43403

Synonyms:SRK, STD, TZK

GeneID:7535