XRCC5 Monoclonal Antibody

SKU: BT-MCA2525

Size:100μL

Background:The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:XRCC5

applications:WB, IHC, ICC, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:5C5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:XRCC5

Immunogen:Purified recombinant fragment of human XRCC5 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):86kDa

UniProt accession:P13010

Synonyms:KU80, KUB2, Ku86, NFIV, KARP1, KARP-1, FLJ39089

GeneID:7520