WRN Polyclonal Antibody

SKU: E-AB-53558

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:WRN

Target Synonym:DKFZp686C2056;DNA helicase;DNA helicase; RecQ like type 3;Exonuclease WRN;HGNC 12791;OTTHUMP00000225301;RecQ protein-like 2;RecQ-like type 3;RecQ3;RECQL2;RECQL3;Werner syndrome ATP-dependent helicase;Werner syndrome helicase;Werner syndrome protein;Werner syndrome; RecQ helicase like;WRN;WRN

Research Areas:Cancer;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q14191

Accession:

Background:This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Concentration:0.8 mg/mL

Immunogen:Synthetic peptide of human WRN

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:IHC 1:30-1:150

Calculated MW:

ObservedMW: