WIPI2 Rabbit rabbit pAb

SKU: ES20596

Size: 100μL

Source:Rabbit

Applications:IHC;IF

Reactivity:Human;Mouse;Rat

Dilution:IHC-p 1:50-300

Immunogen:Recombinant Protein of WIPI2

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):49kD

Human_gene_id:26100

Human_swiss_prot_no:Q9Y4P8

Subcellular_location:Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .

Other_name:WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2;WIPI49-like protein 2)

Background:WD repeat domain, phosphoinositide interacting 2(WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008],