WDR5 Monoclonal Antibody

SKU: BT-MCA4591

Size:100μL

Background:WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.

Research_area:Epigenetics and nuclear signaling

Target_protein:WDR5

applications:WB

Reactivity:Human

Clonality:Monoclonal

Clone ID:7B11

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:WDR5

Immunogen:Purified recombinant fragment of human WDR5 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):36.6kDa

UniProt accession:P61964

Synonyms:SWD3, BIG-3, WDR5

GeneID:11091