WDR24 Antibody, Biotin conjugated - Cat. #: CSB-PA836297LD01HU

SKU: CSB-PA836297LD01HU

Size :50ul

Clone Number:

Aliases:C16orf21 antibody; DKFZp434F054 antibody; JFP7 antibody; LA16c-313D11.2 antibody; WD repeat-containing protein 24 antibody; wdr24 antibody; WDR24_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96S15

Immunogen:Recombinant Human GATOR complex protein WDR24 protein (1-298AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:WDR24

Research Areas:Cell biology