WDFY3 antibody , Cat. # FNab09479

SKU: FNab09479

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Required for selective autophagy(aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies(p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

Immunogen:WD repeat and FYVE domain containing 3

Synonyms:ALFY, Autophagy linked FYVE protein, KIAA0993, WDFY3, ZFYVE25

Observed MW:

Uniprot ID:Q8IZQ1

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC

Recommended dilution:IHC: 1:20-1:200

Gene ID:23001

Research Area:Cardiovascular, Signal Transduction