VRK1 Polyclonal Antibody

SKU: E-AB-52422

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:VRK1

Target Synonym:MGC117401;MGC138280;MGC142070;PCH1;PCH1A;Serine/threonine protein kinase VRK1;Serine/threonine-protein kinase VRK1;Vaccinia related kinase 1 ;Vaccinia virus B1R related kinase 1;Vaccinia-related kinase 1;VRK1;VRK1

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Signal transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q99986

Accession:

Background:This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Concentration:0.5 mg/mL

Immunogen:Fusion protein of human VRK1

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000;IHC 1:25-1:100

Calculated MW:45 kDa

ObservedMW:Refer to figures