VRK1 Antibody - Cat. #: CSB-PA857466DSR1HU

SKU: CSB-PA857466DSR1HU

Size :50ul

Clone Number:

Aliases:MGC117401 antibody; MGC138280 antibody; MGC142070 antibody; PCH1 antibody; PCH1A antibody; Serine/threonine protein kinase VRK1 antibody; Serine/threonine-protein kinase VRK1 antibody; Vaccinia related kinase 1 antibody; Vaccinia virus B1R related kinase 1 antibody; Vaccinia-related kinase 1 antibody; VRK1 antibody; VRK1_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q99986

Immunogen:Recombinant Human Serine/threonine-protein kinase VRK1 protein (257-396AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates \\\'Thr-18\\\' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:VRK1

Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction