VPS4B Antibody, Biotin conjugated - Cat. #: CSB-PA025915LD01HU

SKU: CSB-PA025915LD01HU

Size :50ug

Clone Number:

Aliases:8030489C12Rik antibody; Cell migration inducing 1 antibody; Cell migration-inducing gene 1 protein antibody; MGC116271 antibody; MIG1 antibody; Protein SKD1 antibody; Skd1 antibody; SKD1B antibody; Suppressor of K(+) transport growth defect 1 antibody; Suppressor of K+ transport defect 1 antibody; Vacuolar protein sorting 4 homolog B (S. cerevisiae) antibody; Vacuolar protein sorting 4 homolog B antibody; Vacuolar protein sorting 4b antibody; Vacuolar protein sorting-associated protein 4B antibody; Vacuolar protein sorting-associating protein 4B antibody; VPS4 2 antibody; VPS42 antibody; Vps4b antibody; VPS4B_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75351

Immunogen:Recombinant Human Vacuolar protein sorting-associated protein 4B protein (1-117AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:VPS4B

Research Areas:Signal transduction