USP20 Antibody, FITC conjugated - Cat. #: CSB-PA896876LC01HU

SKU: CSB-PA896876LC01HU

Size :50ug

Clone Number:

Aliases:Deubiquitinating enzyme 20 antibody; hVDU2 antibody; KIAA1003 antibody; LSFR 3A antibody; LSFR3A antibody; pVHL interacting deubiquitinating enzyme 2 antibody; Ubiquitin carboxyl terminal hydrolase 20 antibody; Ubiquitin carboxyl-terminal hydrolase 20 antibody; ubiquitin specific peptidase 20 antibody; Ubiquitin specific processing protease 20 antibody; Ubiquitin specific protease 20 antibody; Ubiquitin thioesterase 20 antibody; Ubiquitin thiolesterase 20 antibody; Ubiquitin-specific-processing protease 20 antibody; UBP20_HUMAN antibody; USP 20 antibody; USP20 antibody; VDU 2 antibody; VDU2 antibody; VHL interacting deubiquitinating enzyme 2 antibody; VHL-interacting deubiquitinating enzyme 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y2K6

Immunogen:Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 protein (258-417AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:USP20

Research Areas:Epigenetics and Nuclear Signaling; Cell biology