UNC5B Antibody, FITC conjugated - Cat. #: CSB-PA025629LC01HU

SKU: CSB-PA025629LC01HU

Size :50ug

Clone Number:

Aliases:6330415E02Rik antibody; A630020F16 antibody; D10Bwg0792e antibody; Netrin receptor UNC5B antibody; Netrin receptor UNC5B Precursor antibody; p53 regulated receptor for death and life antibody; p53 regulated receptor for death and life protein 1 antibody; p53-regulated receptor for death and life protein 1 antibody; p53RDL1 antibody; Protein unc-5 homolog 2 antibody; Protein unc-5 homolog B antibody; Protein XUNC 5 antibody; Transmembrane receptor Unc5H2 antibody; Unc 5 homolog 2 antibody; Unc 5 homolog B antibody; Unc 5 netrin receptor B antibody; UNC 5B antibody; Unc5 (C.elegans homolog) b antibody; Unc5b antibody; UNC5B_HUMAN antibody; UNC5H2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8IZJ1

Immunogen:Recombinant Human Netrin receptor UNC5B protein (404-517AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:UNC5B

Research Areas:Neuroscience; Cardiovascular; Signal transduction