UBE2K Antibody, HRP conjugated - Cat. #: CSB-PA09667B0Rb

SKU: CSB-PA09667B0Rb

Size :50ug

Clone Number:

Aliases:E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; Ubiquitin carrier protein antibody; Ubiquitin conjugating enzyme E2 25 kDa antibody; ubiquitin conjugating enzyme E2K antibody; ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody; Ubiquitin protein ligase antibody; Ubiquitin-conjugating enzyme E2 K antibody; Ubiquitin-conjugating enzyme E2(25K) antibody; Ubiquitin-conjugating enzyme E2-25 kDa antibody; Ubiquitin-conjugating enzyme E2-25K antibody; Ubiquitin-protein ligase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P61086

Immunogen:Recombinant Human Ubiquitin-conjugating enzyme E2 K protein (2-200AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of \'Lys-48\'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:UBE2K

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cell biology