TRADD Antibody, Biotin conjugated - Cat. #: CSB-PA621879ED01HU

SKU: CSB-PA621879ED01HU

Size :50ug

Clone Number:

Aliases:9130005N23Rik antibody; AA930854 antibody; TNFR1 associated DEATH domain protein antibody; TNFR1-associated DEATH domain protein antibody; TNFRSF1A associated via death domain antibody; TNFRSF1A-associated via death domain antibody; tradd antibody; TRADD_HUMAN antibody; Tumor necrosis factor receptor type 1 associated DEATH domain protein antibody; Tumor necrosis factor receptor type 1-associated DEATH domain protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q15628

Immunogen:Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TRADD

Research Areas:Cancer; Cardiovascular; Cell biology