TOP2A Monoclonal Antibody

SKU: BT-MCA2526

Size:100μL

Background:This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:TOP2A

applications:WB, IHC

Reactivity:

Clonality:Monoclonal

Clone ID:6D4B2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:TOP2A

Immunogen:Purified recombinant fragment of human TOP2A (AA: 1100-1530) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):174.4kDa

UniProt accession:P11388

Synonyms:TOP2, TP2A

GeneID:7153