TFE3 Antibody - Cat. #: CSB-PA104708

SKU: CSB-PA104708

Size :100ul

Clone Number:

Aliases:bHLH e33 antibody; bHLHe33 antibody; Class E basic helix-loop-helix protein 33 antibody; RCCP 2 antibody; RCCP2 antibody; RCCX1 antibody; Renal cell carcinoma, papillary antibody; Tcfe 3 antibody; Tcfe3 antibody; TFE 3 antibody; Tfe3 antibody; TFE3_HUMAN antibody; TFEA antibody; Transcription factor binding to IGHM enhancer 3 antibody; Transcription factor E family, member A antibody; Transcription factor E3 antibody; Transcription factor for IgH enhancer antibody; Transcription factor for immunoglobulin heavy chain enhancer 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P19532

Immunogen:Peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

Clark J., Lu Y.-J., Sidhar S.K., Parker C., Gill S. Oncogene 15:2233-2239(1997) Weterman M.A.J., Wilbrink M., Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298(1996)

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TFE3

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Immunology