SYK (Ab-323) Antibody - Cat. #: CSB-PA572454

SKU: CSB-PA572454

Size :100ul

Clone Number:

Aliases:EC 2.7.10.2 antibody; kinase Syk antibody; KSYK antibody; KSYK_HUMAN antibody; p72-Syk antibody; p72syk antibody; Spleen tyrosine kinase antibody; Syk antibody; Tyrosine protein kinase SYK antibody; Tyrosine-protein kinase SYK antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P43405

Immunogen:Peptide sequence around aa. 321~325 (N-P-Y-E-P) derived from Human syk.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Background:Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447.
Turner, M. et al. (2000) Immunol. Today 21, 148-154.
Decker, M. et al. (1998) J. Biol. Chem. 273, 8867-8874.
Law, C.L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SYK

Research Areas:Cardiovascular;Immunology;Signal transduction