STAT5B Monoclonal Antibody

SKU: BT-MCA4254

Size:100μL

Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Research_area:Signal transduction, Epigenetics and nuclear signaling, Cancer, Metabolism

Target_protein:STAT5B

applications:WB

Reactivity:Human

Clonality:Monoclonal

Clone ID:5B3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:STAT5B

Immunogen:Purified recombinant fragment of human STAT5B expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):90kDa

UniProt accession:P51692

Synonyms:STAT5, STAT5B

GeneID:6777