Stat5(Phospho-Tyr694) Rabbit Polyclonal Antibody

SKU: BT-AP12838

Size:100μL

Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands| such as IL2| IL4| CSF1| and different growth hormones. It has been shown to be involved in diverse biological processes| such as TCR signaling| apoptosis| adult mammary gland development| and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Research_area:Epigenetics and nuclear signaling; Cancer; Signal transduction; Metabolism

Target_protein:STAT5B

applications:WB

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Stat5

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P51692; Mouse: P42232; Rat: P52632

Synonyms:Stat5 ;Tyr694; Signal transducer and activator of transcription 5B

GeneID:Human: 6777; Mouse: 20851; Rat: 25126