STAMBP Antibody, HRP conjugated - Cat. #: CSB-PA022794HB01HU

SKU: CSB-PA022794HB01HU

Size :50ug

Clone Number:

Aliases:AMSH antibody; Associated molecule with the SH3 domain of STAM antibody; Endosome associated ubiquitin isopeptidase antibody; Endosome-associated ubiquitin isopeptidase antibody; MGC126516 antibody; MGC126518 antibody; MICCAP antibody; STABP_HUMAN antibody; STAM binding protein antibody; STAM-binding protein antibody; Stambp antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95630

Immunogen:Recombinant Human STAM-binding protein (1-424AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Zinc metalloprotease that specifically cleaves \'Lys-63\'-linked polyubiquitin chains. Does not cleave \'Lys-48\'-linked polyubiquitin chains.Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization .Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:STAMBP

Research Areas:Epigenetics and Nuclear Signaling; Cell biology