SRY Antibody - Cat. #: CSB-PA985423

SKU: CSB-PA985423

Size :100ul

Clone Number:

Aliases:Essential protein for sex determination in human males antibody; Sex determining region on Y antibody; Sex determining region protein antibody; Sex determining region Y antibody; Sex-determining region Y protein antibody; sox21b antibody; SRXX1 antibody; SRXY1 antibody; SRY 1 antibody; SRY antibody; SRY_HUMAN antibody; Sry1 antibody; Sry3BI antibody; SRYGENE antibody; TDF antibody; TDY antibody; Testis determining factor antibody; Testis Determining Factor on Y antibody; Testis-determining factor antibody; Transcription factor Sox-21-B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q05066

Immunogen:Synthesized peptide derived from internal of Human SRY.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells By similarity. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons By similarity. Involved in different aspects of gene regulation including promoter activation or repression By similarity. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.

Sinclair A.H., Nature 346:240-244(1990).
Su H., Am. J. Hum. Genet. 52:24-38(1993).
Behlke M.A., Genomics 17:736-739(1993).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SRY

Research Areas:Epigenetics and Nuclear Signaling;Developmental biology