SQSTM1 Polyclonal Antibody

SKU: E-AB-19884

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: SQSTM1

Target Synonym: A170;DMRV;EBI 3 associated protein of 60 kDa;EBI 3 associated protein p60;EBI3 associated protein of 60 kDa;EBI3 associated protein p60;EBI3-associated protein of 60 kDa;EBIAP;FTDALS3;MGC127197;ORCA;OSF-6;Osi;OSIL;Oxidative stress induced like;p60;p62;p62B;Paget disease of bone 3;PDB 3;PDB3;Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa;Phosphotyrosine independent ligand for the Lck SH2 domain p62;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;PKC-zeta-interacting protein;Protein kinase C-zeta-interacting protein;Sequestosome 1;Sequestosome-1;SQSTM 1;SQSTM;Sqstm1;STAP;STONE14;Ubiquitin binding protein p62;Ubiquitin-binding protein p62;ZIP 3;ZIP;ZIP3

Research Areas: Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q13501

Accession:

Background: Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.

Concentration: 1.14 mg/mL

Immunogen: Synthetic peptide of human SQSTM1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:500-1:2000;IHC 1:50-1:100

Calculated MW: 48 kDa

ObservedMW: Refer to figures